对55例系统性淀粉样变性患者进行免疫电泳研究。
Immunoelectrophoretic investigations in 55 patients with systemic amyloidosis.
作者信息
Vital Durand D, Touraine J L, Levrat R, Zech P, Traeger J, Lejeune E, Creyssel R
出版信息
Blut. 1984 Aug;49(2):91-4. doi: 10.1007/BF00363699.
PMID:6380625
Abstract
Among 55 amyloidoses, the detection of a monoclonal protein (MP) led to the selection of 15 primary and 3 myeloma-associated types of amyloidosis. Therefore the presence of a MP gives evidence for an immunocytic amyloidosis. The lambda-light-chain nature of MP and the abundant production of free light-chains are two of the factors predisposing to the production of amyloid deposits (AL) in the course of immunocyte dyscrasias.
摘要
在55种淀粉样变性中，单克隆蛋白（MP）的检测导致15种原发性淀粉样变性和3种骨髓瘤相关淀粉样变性被筛选出来。因此，MP的存在为免疫细胞性淀粉样变性提供了证据。MP的λ轻链性质和游离轻链的大量产生是免疫细胞发育异常过程中易导致淀粉样沉积物（AL）产生的两个因素。
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