骨髓瘤相关性系统性淀粉样变性中一种淀粉样变性本-周蛋白的氨基酸序列。
Amino acid sequence of an amyloidogenic Bence Jones protein in myeloma-associated systemic amyloidosis.
作者信息
Tonoike H, Kametani F, Hoshi A, Shinoda T, Isobe T
出版信息
FEBS Lett. 1985 Jun 3;185(1):139-41. doi: 10.1016/0014-5793(85)80757-2.
The complete amino acid sequence of an amyloidogenic Bence Jones protein (NIG-84) from an individual with myeloma-associated systemic amyloidosis has been determined. The protein, with a blocked N-terminus, represents a complete light chain consisting of 217 residues and it has a structural feature characteristic of the V lambda II subgroup. In addition to a two-residue insertion at positions 28 and 29, it has an additional rare insertion of alanine at position 100. NIG-84 is an example of the first complete sequence presented for the amyloidogenic Bence Jones protein of the V lambda II subgroup.
已确定一名患有骨髓瘤相关性系统性淀粉样变性患者的淀粉样变本斯-琼斯蛋白（NIG-84）的完整氨基酸序列。该蛋白N端封闭，代表一条由217个残基组成的完整轻链，具有VλII亚组特有的结构特征。除了在第28和29位有两个残基插入外，它在第100位还有一个额外的罕见丙氨酸插入。NIG-84是VλII亚组淀粉样变本斯-琼斯蛋白首个完整序列的实例。
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