White G C, Jacobson R J, Binder R A, Linke R P, Glenner G G
Blood. 1975 Nov;46(5):713-22.
Urinary Bence Jones protein and amyloid fibril protein isolated from the subcutaneous tissue of a patient with IgD myeloma and associated amyloidosis were subjected to physicochemical and immunochemical identification. Peptide maps and amino-terminal tetrapeptide composition obtained from the two proteins were comparable. Immunochemical cross-reactivity between the two proteins, with other lambda-type amyloid and Bence Jones proteins, and with a serum component was demonstrated. The results suggest that the source of the amyloid fibril protein is an intact circulating light polypeptide chain as well as smaller amino-terminal fragments.
从一名患有IgD骨髓瘤及相关淀粉样变性病患者的皮下组织中分离出的尿本-周蛋白和淀粉样原纤维蛋白，进行了物理化学和免疫化学鉴定。从这两种蛋白获得的肽图和氨基末端四肽组成具有可比性。证明了这两种蛋白之间、与其他λ型淀粉样蛋白和本-周蛋白以及与一种血清成分之间的免疫化学交叉反应性。结果表明，淀粉样原纤维蛋白的来源是完整的循环轻多肽链以及较小的氨基末端片段。
