Danguir J, Nicolaidis S
Brain Res. 1984 Jul 23;306(1-2):97-103. doi: 10.1016/0006-8993(84)90359-7.
Sleep patterns were continuously recorded in rats receiving chronic intracerebroventricular (i.c.v.) infusions of insulin. The i.c.v. administration of insulin resulted in a selective increase (25%) of the daily duration of slow wave sleep (SWS), whereas the duration of paradoxical sleep (PS) remained unchanged. The neutralization of peripheral and/or central insulin by means of continuous intravenous or i.c.v. infusions of anti-insulin serum brought about a selective decrease of SWS, whereas PS remained unchanged. The present findings are discussed with regard to the present knowledge of the origin and the role of brain insulin.
对接受慢性脑室内（i.c.v.）注射胰岛素的大鼠的睡眠模式进行了连续记录。脑室内注射胰岛素导致慢波睡眠（SWS）的每日时长选择性增加（25%），而异相睡眠（PS）的时长保持不变。通过连续静脉注射或脑室内注射抗胰岛素血清来中和外周和/或中枢胰岛素，会导致慢波睡眠选择性减少，而异相睡眠则保持不变。结合目前对脑胰岛素的起源和作用的了解，对本研究结果进行了讨论。
