Danguir J, Elghozi J L
Brain Res Bull. 1985 Jul;15(1):1-4. doi: 10.1016/0361-9230(85)90053-x.
Sleep patterns were continuously recorded in rats which received during 2 hours and a half a push-pull superfusion of clomipramine at 10(-6) mol/l or 10(-8) mol/l concentrations, within the ventromedial hypothalamus. The superfusion of 10(-6) mol/l clomipramine resulted in a suppression of paradoxical sleep (PS) and a reduction of slow wave sleep (SWS), whereas lower concentrations of this drug (10(-8) mol/l) suppressed PS but did not affect SWS. In both cases, a secondary rebound of PS was observed. These findings are discussed with regard to the present knowledge of the role of the hypothalamus in sleep.
对大鼠的睡眠模式进行持续记录，这些大鼠在腹内侧下丘脑接受了两个半小时的10(-6)摩尔/升或10(-8)摩尔/升氯米帕明推挽式灌注。10(-6)摩尔/升氯米帕明的灌注导致异相睡眠（PS）受到抑制，慢波睡眠（SWS）减少，而较低浓度的该药物（10(-8)摩尔/升）抑制了PS，但不影响SWS。在这两种情况下，均观察到PS的继发性反跳。根据目前关于下丘脑在睡眠中作用的知识对这些发现进行了讨论。
