对照组和巨幼细胞贫血患者淋巴细胞中叶酸依赖性丝氨酸合成：治疗的影响
Folate-dependent serine synthesis in lymphocytes from controls and patients with megaloblastic anaemia: the effect of therapy.
作者信息
Tikerpae J, Chanarin I
出版信息
Br J Haematol. 1978 Mar;38(3):353-8. doi: 10.1111/j.1365-2141.1978.tb01054.x.
Abstract
The utilization of [14C]formate for serine synthesis by lymphocytes was impaired in all the patients with pernicious anaemia and in 70% of other patients with megaloblastic anaemia. In pernicious anaemia this was corrected by vitamin B12 therapy in 48 h but not by folate therapy although patients given folate showed a satisfactory haematological response.
摘要
在所有恶性贫血患者以及70%的其他巨幼细胞贫血患者中，淋巴细胞利用[14C]甲酸合成丝氨酸的能力受损。在恶性贫血中，维生素B12治疗可在48小时内纠正这一情况，但叶酸治疗无效，尽管给予叶酸的患者血液学反应良好。
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