Clin Pharmacol Ther. 1984 Sep;36(3):307-14. doi: 10.1038/clpt.1984.180.
The time course of various doses of captopril (C) alone, hydrochlorothiazide (H) alone, and C with H was followed in 142 subjects with mild hypertension. Doses of C were 12.5, 25, and 50 mg three times daily or 37.5 mg twice daily and dose of H was 25 mg twice daily. Time-course measurements were made during continuous treatment, with morning dose omitted on the test day. After C alone, diastolic blood pressure (BP) fell to its lowest point 2 to 5 hr and then gradually returned toward baseline. Reductions from levels before treatment were present 13 hr after a dose and there were no significant differences between various doses of C at that time. Systolic BP fell only with the larger doses. When C was combined with H, both systolic and diastolic BP decreased more than with either C or H alone, reaching a nadir at 2 hr. BP remained significantly below levels before treatment for at least 13 hr after dosing. Except for the response to the lowest (12.5 mg) dose, small doses of C alone had the same effect as large doses on both degree and duration of antihypertensive response. Effect was considerably enhanced by addition of a thiazide diuretic.
在142例轻度高血压患者中，观察了单独使用不同剂量卡托普利（C）、氢氯噻嗪（H）以及C与H联合使用后的时间进程。C的剂量为每日3次，每次12.5、25和50mg或每日2次，每次37.5mg，H的剂量为每日2次，每次25mg。在持续治疗期间进行时间进程测量，测试日省略晨服剂量。单独使用C后，舒张压（BP）在2至5小时降至最低点，然后逐渐恢复至基线水平。给药后13小时仍低于治疗前水平，此时不同剂量的C之间无显著差异。仅大剂量C可使收缩压下降。当C与H联合使用时，收缩压和舒张压的下降幅度均大于单独使用C或H，在2小时达到最低点。给药后至少13小时，血压仍显著低于治疗前水平。除对最低剂量（12.5mg）的反应外，小剂量C单独使用在降压反应的程度和持续时间上与大剂量相同。添加噻嗪类利尿剂可显著增强疗效。
