Brosens I A, Koninckx P R, Corveleyn P A
Br J Obstet Gynaecol. 1978 Apr;85(4):246-50. doi: 10.1111/j.1471-0528.1978.tb10494.x.
Thirty-four infertile patients with regular cycles and endometriosis were studied and compared to a control group of 28 women. The endometriosis was classified as mild (n = 16), moderate (n = 9) and severe (n = 9) according to Acosta et al (1973). The interval between the LH peak and the onset of subsequent menstruation was shorter (P = 0.024) in patients with endometriosis than in the control group. In mild endometriosis, oestradiol-17beta levels fell on the day after the LH peak, but this was not the case in moderate and severe endometriosis. In mild, moderate and severe endometriosis the plasma progesterone concentration did not rise on the first day following the LH peak, and at laparoscopy significantly (P less than 0.005) less ovulation stigmata were present. We conclude that endometriosis is associated with luteinization in situ and that this may explain the associated infertility.
对34例月经周期规律且患有子宫内膜异位症的不孕患者进行了研究，并与28名女性组成的对照组进行比较。根据阿科斯塔等人（1973年）的标准，将子宫内膜异位症分为轻度（n = 16）、中度（n = 9）和重度（n = 9）。与对照组相比，子宫内膜异位症患者促黄体生成素（LH）峰值与随后月经开始之间的间隔更短（P = 0.024）。在轻度子宫内膜异位症中，促卵泡生成素峰值后一天雌二醇-17β水平下降，但中度和重度子宫内膜异位症并非如此。在轻度、中度和重度子宫内膜异位症中，LH峰值后的第一天血浆孕酮浓度并未升高，并且在腹腔镜检查时，排卵点明显较少（P小于0.005）。我们得出结论，子宫内膜异位症与原位黄素化有关，这可能解释了相关的不孕症。
