Mamer O A, Montgomery J A, Tjoa S S, Crawhall J C, Feldkamp C S
Biomed Mass Spectrom. 1978 Apr;5(4):287-90. doi: 10.1002/bms.1200050403.
Several organic acids, among them the acidic catabolites of the branched chain amino acids and tyrosine, have been found to be elevated in the sera of non-diabetic patients presenting acute ketoacidosis associated with alcohol abuse. These findings are interpreted in terms of insufficiency of dietary co-factors required for their further catabolism. Butane-2,3-diol is also found frequently elevated in the urine of these patients and suggests interception of hydroxyethyl thiamine pyrophosphate by circulating high levels of acetaldehyde.
已发现几种有机酸，其中包括支链氨基酸和酪氨酸的酸性分解代谢产物，在患有与酒精滥用相关的急性酮症酸中毒的非糖尿病患者血清中升高。这些发现被解释为其进一步分解代谢所需的膳食辅助因子不足。丁烷 - 2,3 - 二醇在这些患者的尿液中也经常被发现升高，这表明循环中高水平的乙醛会截留羟乙基硫胺焦磷酸。
