氨甲环酸预防脑室周围出血

Tranexamic acid in the prevention of periventricular haemorrhage.

作者信息

Hensey O J, Morgan M E, Cooke R W

出版信息

Arch Dis Child. 1984 Aug;59(8):719-21. doi: 10.1136/adc.59.8.719.

DOI:10.1136/adc.59.8.719

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1628624/

Abstract

Increased fibrinolytic activity in the ganglionic eminence of the preterm human brain has been proposed as a factor in the aetiology of periventricular haemorrhage. The effect of tranexamic acid in preventing periventricular haemorrhage was evaluated in 100 infants in a double blind, randomised controlled trial. Haemorrhages developed in 22 infants who received tranexamic acid and in 20 of those who received placebo. A significant reduction in fibrin degradation products in treated infants was seen. Our study suggests that excessive fibrinolytic activity is not an important factor in the aetiology of periventricular haemorrhage and that treatment with tranexamic acid will not prevent its occurrence.

摘要

早产人类大脑神经节隆起处纤溶活性增加被认为是脑室周围出血病因中的一个因素。在一项双盲、随机对照试验中，对100名婴儿评估了氨甲环酸预防脑室周围出血的效果。接受氨甲环酸治疗的22名婴儿以及接受安慰剂治疗的20名婴儿发生了出血。接受治疗的婴儿中纤维蛋白降解产物显著减少。我们的研究表明，过度纤溶活性不是脑室周围出血病因中的重要因素，且氨甲环酸治疗不能预防其发生。

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