Avvisati G, ten Cate J W, Büller H R, Mandelli F
Department of Human Biopathology, University La Sapienza, Rome, Italy.
Lancet. 1989 Jul 15;2(8655):122-4. doi: 10.1016/s0140-6736(89)90181-5.
In a double-blind study, 12 consecutive patients with acute promyelocytic leukaemia were randomised either to tranexamic acid (TA group) or to placebo (control group) for 6 days to see whether inhibition of fibrinolysis would reduce haemorrhage and transfusion requirements. The total study period was 14 days. In the TA group, there were fewer haemorrhagic episodes, as determined by a scoring system. Packed red cell transfusion requirements decreased; and fewer additional platelet concentrate transfusions were needed. These beneficial effects were more pronounced in the second week. There were no thromboembolic complications.
在一项双盲研究中，12例连续的急性早幼粒细胞白血病患者被随机分为氨甲环酸组（TA组）或安慰剂组（对照组），为期6天，以观察纤维蛋白溶解抑制是否会减少出血和输血需求。总研究期为14天。根据评分系统确定，TA组的出血事件较少。浓缩红细胞输血需求减少；额外需要的血小板浓缩液输血也较少。这些有益效果在第二周更为明显。没有血栓栓塞并发症。
