大量上消化道出血患者纤溶系统的局部抑制作用

Local inhibition of the fibrinolytic system in patients with massive upper gastrointestinal hemorrhage.

作者信息

Bergqvist D, Dahlgren S, Hessman Y

出版信息

Ups J Med Sci. 1980;85(2):173-8. doi: 10.3109/03009738009179185.

Abstract

The effect or oral tranexamic acid on massive upper gastrointestinal hemorrhage was evaluated in a randomized double-blind study. Totally 50 patients entered the trial and seven were excluded, leaving 22 placebo treated and 21 tranexamic acid treated for analysis. The groups were comparable regarding sex, age, diagnosis, and initial laboratory data. Transfusions requirements and operation frequency did not differ. Mortality was slightly reduced and death delayed in tranexamic acid treated patients.

摘要

在一项随机双盲研究中评估了口服氨甲环酸对大量上消化道出血的疗效。共有50名患者进入试验，7名被排除，剩余22名接受安慰剂治疗和21名接受氨甲环酸治疗的患者进行分析。两组在性别、年龄、诊断和初始实验室数据方面具有可比性。输血需求和手术频率没有差异。氨甲环酸治疗的患者死亡率略有降低，死亡延迟。