Gusterson B A, Warburton M J, Monaghan P, Foster C, Edwards P, Kraft N, Smith C, Mitchell D, Rudland P S, Neville A M
Behring Inst Mitt. 1984 May(74):39-48.
A review is presented of the use of immunohistochemical probes in the study of the cellular pathology of the breast. Using a combination of monoclonal and polyclonal antisera it has been possible to investigate the relationship between myoepithelial cells and basement membrane components in benign breast disease and the disturbance of this relationship in early invasive and infiltrating ductal carcinomas. The use of immunohistochemical techniques at the ultrastructural level provides the methodology for future detailed analyses. The heterogeneous expression of antigenic determinants characteristic of epithelial cells in the normal breast is considered in conjunction with its relevance to the heterogeneity seen in the invasive tumours.
本文综述了免疫组织化学探针在乳腺细胞病理学研究中的应用。通过使用单克隆和多克隆抗血清的组合，得以研究良性乳腺疾病中肌上皮细胞与基底膜成分之间的关系，以及早期浸润性和浸润性导管癌中这种关系的紊乱。超微结构水平免疫组织化学技术的应用为未来的详细分析提供了方法。结合其与浸润性肿瘤中所见异质性的相关性，考虑了正常乳腺上皮细胞抗原决定簇的异质性表达。
