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Pancreatitis. The role of lysosomes.

作者信息

Steer M L, Meldolesi J, Figarella C

出版信息

Dig Dis Sci. 1984 Oct;29(10):934-8. doi: 10.1007/BF01312483.

DOI:10.1007/BF01312483
PMID:6383748
Abstract
摘要

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1
Pancreatitis. The role of lysosomes.胰腺炎。溶酶体的作用。
Dig Dis Sci. 1984 Oct;29(10):934-8. doi: 10.1007/BF01312483.
2
Localization of lysosomal and digestive enzymes in cytoplasmic vacuoles in caerulein-pancreatitis.蓝蛙肽诱导胰腺炎时溶酶体酶和消化酶在细胞质空泡中的定位
Histochemistry. 1990;94(2):161-70. doi: 10.1007/BF02440183.
3
Immunocytochemical and morphometric analysis of acinar zymogen granules in human acute pancreatitis.人急性胰腺炎腺泡酶原颗粒的免疫细胞化学和形态计量分析
Virchows Arch A Pathol Anat Histopathol. 1989;415(2):115-23. doi: 10.1007/BF00784348.
4
The role of cysteine proteases in intracellular pancreatic serine protease activation.半胱氨酸蛋白酶在细胞内胰腺丝氨酸蛋白酶激活中的作用。
Adv Exp Med Biol. 2000;477:403-11. doi: 10.1007/0-306-46826-3_41.
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Co-localization hypothesis: a mechanism for the intrapancreatic activation of digestive enzymes during the early phases of acute pancreatitis.共定位假说：急性胰腺炎早期胰腺内消化酶激活的一种机制。
World J Gastroenterol. 2006 Apr 7;12(13):1985-90. doi: 10.3748/wjg.v12.i13.1985.
6
[Exocrine pancreatic zymogen activation].[外分泌胰腺酶原激活]
Nihon Shokakibyo Gakkai Zasshi. 2000 May;97(5):560-7.
7
The time course of ultrastructural changes in the secretory components of pancreatic acinar cells and trypsinogen activation in taurocholate pancreatitis in rats.
Rocz Akad Med Bialymst. 1996;41(2):363-73.
8
Possible lysosomal activation of pancreatic zymogens. Activation of both human trypsinogens by cathepsin B and spontaneous acid. Activation of human trypsinogen 1.胰腺酶原可能的溶酶体激活。组织蛋白酶B和自发酸性物质对两种人胰蛋白酶原的激活。人胰蛋白酶原1的激活。
Biol Chem Hoppe Seyler. 1988 May;369 Suppl:293-8.
9
Intra-acinar cell activation of trypsinogen during caerulein-induced pancreatitis in rats.大鼠蛙皮素诱导胰腺炎期间腺泡细胞内胰蛋白酶原的激活
Am J Physiol. 1998 Aug;275(2):G352-62. doi: 10.1152/ajpgi.1998.275.2.G352.
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Immunohistochemical localization of trypsinogen and trypsin in acute and chronic pancreatitis.急性和慢性胰腺炎中胰蛋白酶原和胰蛋白酶的免疫组织化学定位
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Autophagy. 2025 Jan;21(1):210-222. doi: 10.1080/15548627.2024.2392478. Epub 2024 Aug 31.
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Autophagy, Acute Pancreatitis and the Metamorphoses of a Trypsinogen-Activating Organelle.自噬、急性胰腺炎与激活酶原的细胞器的变化。
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α‑lipoic acid inhibits cerulein/resistin‑induced expression of interleukin‑6 by activating peroxisome proliferator‑activated receptor‑γ in pancreatic acinar cells.

本文引用的文献

1
Endogenous cathepsin activation of trypsinogen in extracts of dog pancreas.犬胰腺提取物中胰蛋白酶原的内源性组织蛋白酶激活
Proc Soc Exp Biol Med. 1961 May;107:74-6. doi: 10.3181/00379727-107-26539.
2
[Lactoferrin in chronic calcifying pancreatitis. Hypothesis for the biological role of the protein].[慢性钙化性胰腺炎中的乳铁蛋白。该蛋白质生物学作用的假说]
Gastroenterol Clin Biol. 1980 Oct;4(10):631-5.
3
Acute hemorrhagic pancreatic necrosis in mice: the activity of lysosomal enzymes in the pancreas and the liver.小鼠急性出血性胰腺坏死：胰腺和肝脏中溶酶体酶的活性
α-硫辛酸通过激活胰腺腺泡细胞过氧化物酶体增殖物激活受体-γ抑制雨蛙肽/抵抗素诱导的白细胞介素-6的表达。
Mol Med Rep. 2022 Aug;26(2). doi: 10.3892/mmr.2022.12780. Epub 2022 Jun 22.
4
Cathepsin B and D deficiency in the mouse pancreas induces impaired autophagy and chronic pancreatitis.小鼠胰腺中组织蛋白酶B和D的缺乏会导致自噬受损和慢性胰腺炎。
Sci Rep. 2021 Mar 23;11(1):6596. doi: 10.1038/s41598-021-85898-9.
5
Biochemical Evaluation of the Antioxidant Effects of Hydroxytyrosol on Pancreatitis-Associated Gut Injury.羟基酪醇对胰腺炎相关肠道损伤抗氧化作用的生化评估
Antioxidants (Basel). 2020 Aug 22;9(9):781. doi: 10.3390/antiox9090781.
6
Multifactorial Scores and Biomarkers of Prognosis of Acute Pancreatitis: Applications to Research and Practice.多因素评分和急性胰腺炎预后的生物标志物：在研究和实践中的应用。
Int J Mol Sci. 2020 Jan 4;21(1):338. doi: 10.3390/ijms21010338.
7
Molecular Ghrelin System in the Pancreatic Acinar Cells: The Role of the Polypeptide, Caerulein and Sensory Nerves.胰腺腺泡细胞中的分子 ghrelin 系统：多肽、蓝斑肽和感觉神经的作用。
Int J Mol Sci. 2017 May 2;18(5):929. doi: 10.3390/ijms18050929.
8
Genetic and phenotypic heterogeneity in tropical calcific pancreatitis.热带钙化性胰腺炎的遗传和表型异质性。
World J Gastroenterol. 2014 Dec 14;20(46):17314-23. doi: 10.3748/wjg.v20.i46.17314.
9
Cell death and DAMPs in acute pancreatitis.细胞死亡和 DAMPs 在急性胰腺炎中的作用。
Mol Med. 2014 Oct 29;20(1):466-77. doi: 10.2119/molmed.2014.00117.
10
Neuronostatin ameliorates sodium taurocholate-induced acute pancreatitis in rats.神经元抑素可改善牛磺胆酸钠诱导的大鼠急性胰腺炎。
Dig Dis Sci. 2013 Oct;58(10):2903-7. doi: 10.1007/s10620-013-2753-3.
Am J Pathol. 1980 Jan;98(1):45-59.
4
Alteration of membrane fusion as a cause of acute pancreatitis in the rat.膜融合改变作为大鼠急性胰腺炎的一个病因
Dig Dis Sci. 1982 Nov;27(11):993-1002. doi: 10.1007/BF01391745.
5
Biosynthesis of lysosomal hydrolases: their synthesis in bound polysomes and the role of co- and post-translational processing in determining their subcellular distribution.溶酶体水解酶的生物合成：它们在附着核糖体中的合成以及共翻译和翻译后加工在决定其亚细胞分布中的作用。
J Cell Biol. 1982 Apr;93(1):135-43. doi: 10.1083/jcb.93.1.135.
6
Pancreatic effects of ethionine: blockade of exocytosis and appearance of crinophagy and autophagy precede cellular necrosis.乙硫氨酸对胰腺的影响：胞吐作用的阻断以及自噬和自噬现象的出现先于细胞坏死。
Am J Physiol. 1982 Apr;242(4):G297-307. doi: 10.1152/ajpgi.1982.242.4.G297.
7
Alkaline phosphatase and acid lysosomal hydrolases in pancreatic juice and fibroblast cell cultures of patients with chronic calcifying pancreatitis.
Eur J Clin Invest. 1982 Apr;12(2):145-9. doi: 10.1111/j.1365-2362.1982.tb00951.x.
8
Supramaximal caerulein stimulation and ultrastructure of rat pancreatic acinar cell: early morphological changes during development of experimental pancreatitis.大鼠胰腺腺泡细胞的超最大剂量蛙皮素刺激与超微结构：实验性胰腺炎发展过程中的早期形态学变化
Am J Physiol. 1984 Apr;246(4 Pt 1):G457-67. doi: 10.1152/ajpgi.1984.246.4.G457.
9
Proteolysis of human trypsinogen 1. Pathogenic implication in chronic pancreatitis.人胰蛋白酶原1的蛋白水解作用。对慢性胰腺炎的致病意义。
Biochem Biophys Res Commun. 1984 Jan 13;118(1):154-61. doi: 10.1016/0006-291x(84)91080-5.
10
Alpha 1-proteinase inhibitor in pure human pancreatic juice. Characterization of a complexed form in patients with chronic calcifying pancreatitis and its significance.
Hoppe Seylers Z Physiol Chem. 1983 Nov;364(11):1597-601. doi: 10.1515/bchm2.1983.364.2.1597.