Norris C S, Pfeiffer J S, Rittgers S E, Barnes R W
J Vasc Surg. 1984 Jan;1(1):192-201. doi: 10.1067/mva.1984.avs0010192.
Doppler ultrasound was used to detect experimental and clinical renal artery stenosis (RAS) and increased renovascular resistance (RVR). Parameters assessing RAS included elevated systolic frequency and spectral broadening, while diastolic/systolic frequency ratios predicted elevated RVR. In canine models these parameters detected graded RAS before reduction in renal blood flow. Index values were 88% sensitive and 100% specific in identifying RAS with gradients greater than or equal to 25 mm Hg. Diastolic/systolic frequency correlated well with increased RVR induced by microsphere injections (p less than 0.05). Duplex scanning noninvasively detected bilateral renal artery velocity in 113 of 120 patients. Index values were 83% sensitive and 97% specific in identifying greater than or equal to 60% RAS in 86 vessels visualized by angiography. Estimated RVR was significantly higher in age-matched hypertensive and atherosclerotic patients than in controls (p less than 0.01). Ultrasound may be useful to screen patients for RAS and increased RVR.
多普勒超声用于检测实验性和临床肾动脉狭窄（RAS）以及肾血管阻力（RVR）升高。评估RAS的参数包括收缩期频率升高和频谱增宽，而舒张期/收缩期频率比值可预测RVR升高。在犬类模型中，这些参数在肾血流量降低之前就能检测出分级RAS。指数值在识别梯度大于或等于25 mmHg的RAS时，敏感性为88%，特异性为100%。舒张期/收缩期频率与微球注射诱导的RVR升高密切相关（p小于0.05）。在120例患者中，双功扫描无创检测出113例患者的双侧肾动脉血流速度。在血管造影显示的86条血管中，指数值在识别大于或等于60%的RAS时，敏感性为83%，特异性为97%。在年龄匹配的高血压和动脉粥样硬化患者中，估计的RVR显著高于对照组（p小于0.01）。超声可能有助于筛查RAS和RVR升高的患者。
