Javadpour N, Vafrier J, Worsham G F, O'Connel K
J Surg Oncol. 1984 Oct;27(2):112-5. doi: 10.1002/jso.2930270211.
We have previously demonstrated that the presence or absence of ABO(H) cell surface antigens correlated with stage, grade, and prognosis of patients with bladder cancer. However, because of the weak antigenecity of 0(H), certain investigators have reported a high rate of false-negative results utilizing specific red cell adherence (SRCA) test of Davidsohn. Since approximately 45% of the population is blood group O(H), this high rate of false-negative result renders the test unreliable in an ordinary laboratory. The present study is comparing the results of SRCA to that of peroxidase antiperoxidase (PAP) technique in a double-blind fashion in 29 patients with bladder cancer having O(H) blood group. In terms of grade, stage, frequency of recurrent tumor, and quality of slides, the results of PAP is superior over SRCA. Furthermore, the convenience, permanence, and ready availability of PAP will enhance the utility of this test in a conventional histopathologic laboratory with a high rate of accuracy and reproducibility.
我们之前已经证明，ABO(H)细胞表面抗原的有无与膀胱癌患者的分期、分级及预后相关。然而，由于O(H)的抗原性较弱，某些研究者报告称，使用戴维森的特异性红细胞黏附（SRCA）试验时假阴性结果发生率很高。由于约45%的人群为O(H)血型，如此高的假阴性率使得该试验在普通实验室中不可靠。本研究以双盲方式比较了29例O(H)血型膀胱癌患者的SRCA结果与过氧化物酶抗过氧化物酶（PAP）技术的结果。在分级、分期、肿瘤复发频率及切片质量方面，PAP的结果优于SRCA。此外，PAP的便利性、永久性及随时可用性将提高该试验在传统组织病理学实验室中的实用性，且准确率和可重复性很高。
