Kato T
Tohoku J Exp Med. 1977 Mar;121(3):239-46. doi: 10.1620/tjem.121.239.
A, B and H(O) blood group antigens in some tissues are readily demonstrable by the specific red cell adherence test (SRCA) which is a modification of Coomb's mixed cell adherence technique. Paraffin-embedded tissue sections obtained from tumors of the urinary bladder were submitted to SRCA. Normal bladder epithelium adjacent to neoplastic lesions and the leukoplakia were found to contain the three antigens. The antigens were completely absent in 18 cases and partially present in one of the bladder carcinoma. It was also suggested that the prognosis of the tumor correlates with the antigen loss. SRCA is sensitive, reproducible and technically easy for detection of tissue antigens, and it would be expected to play a crucial role for demonstration of immunological dedifferentiation in tissues which normally keep the antigens.
某些组织中的A、B和H（O）血型抗原可通过特异性红细胞黏附试验（SRCA）轻易检测出来，该试验是对库姆斯混合细胞黏附技术的改良。从膀胱肿瘤获取的石蜡包埋组织切片进行了SRCA检测。发现肿瘤旁的正常膀胱上皮和白斑含有这三种抗原。18例膀胱癌中抗原完全缺失，1例部分存在。还表明肿瘤的预后与抗原缺失相关。SRCA检测组织抗原灵敏、可重复且技术操作简便，有望在显示正常保留抗原的组织中的免疫去分化方面发挥关键作用。
