Klintmalm G, Säwe J, von Bahr C, Ringdén O, Lundgren G, Wilczek H, Tydén G, Groth C G
Transplant Proc. 1984 Oct;16(5):1208-11.
To avoid nephrotoxicity and hepatotoxicity the CsA-PL should be kept at less than 500 ng/mL during the first month after transplantation and less than 200 ng/mL after four months. After ten months most patients in this study had a CsA-PL of less than 150 ng/mL and many had levels of less than 50 ng/mL with an apparently good immunosuppressive effect. Rejections showed no correlation with high or low CsA-PL. Continuous monitoring of CsA-PL is recommended for the management of renal allograft recipients.
为避免肾毒性和肝毒性，移植后第一个月环孢素A-磷脂（CsA-PL）应保持在500 ng/mL以下，四个月后应保持在200 ng/mL以下。十个月后，本研究中的大多数患者CsA-PL低于150 ng/mL，许多患者的水平低于50 ng/mL，且免疫抑制效果明显良好。排斥反应与CsA-PL的高低无关。建议对肾移植受者进行CsA-PL的持续监测。
