新型多巴胺阻断剂（奥昔哌隆）对帕金森病药物诱发的运动障碍和自发性运动障碍的影响。
Effect of new dopamine-blocking agent (oxiperomide) on drug-induced dyskinesias in Parkinson's disease and spontaneous dyskinesias.
作者信息
Bédard P, Parkes J D, Marsden C D
出版信息
Br Med J. 1978 Apr 15;1(6118):954-6. doi: 10.1136/bmj.1.6118.954.
Abstract
Oxiperomide, a new dopamine-receptor antagonist, was found to decrease dyskinesias in patients with Parkinson's disease receiving levodopa or other dopamine agonists without necessarily increasing Parkinsonian symptoms. Oxiperomide also decreased spontaneous dyskinesias in those with tics and chorea and to a less extent in those with torsion dystonia, without necessarily causing Parkinsonism. These results provide evidence that more than one population of dopamine receptors exist in the extra pyramidal system, and encourage the search for selective dopamine antagonists.
摘要
奥昔哌醇是一种新型多巴胺受体拮抗剂，研究发现它能减轻接受左旋多巴或其他多巴胺激动剂治疗的帕金森病患者的运动障碍，且不一定会加重帕金森症状。奥昔哌醇还能减轻患有抽搐和舞蹈症患者的自发性运动障碍，对患有扭转性肌张力障碍的患者也有一定程度的减轻作用，且不一定会引发帕金森综合征。这些结果证明锥体外系中存在不止一种多巴胺受体群体，并促使人们去寻找选择性多巴胺拮抗剂。
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本文引用的文献
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