胃复安和匹莫齐特在帕金森病及左旋多巴诱发的异动症中的应用
Metoclopramide and pimozide in Parkinson's disease and levodopa-induced dyskinesias.
作者信息
Tarsy D, Parkes J D, Marsden C D
出版信息
J Neurol Neurosurg Psychiatry. 1975 Apr;38(4):331-5. doi: 10.1136/jnnp.38.4.331.
Abstract
Metoclopramide is an antiemetic drug which occasionally produced acute dystonic reactions. Although known to interfere with central dopamine mechanisms, it is frequently used in Parkinson's disease to prevent levodopa-induced nausea and vomiting. In this study metoclopramide did not increase Parkinsonism or reduce levodopa-induced involuntary movements in patients with Parkinson's disease. Pimozide, by contrast, increased Parkinsonism and reduced involuntary movements. The capacity of metoclopramide to produce acute dyskinesias while being apparently free of Parkinsonism effects is pharmacologically unique and differentiates this drug from the phenothiazines and butyrophenones.
摘要
甲氧氯普胺是一种止吐药，偶尔会引起急性肌张力障碍反应。尽管已知它会干扰中枢多巴胺机制，但它仍常用于帕金森病，以预防左旋多巴引起的恶心和呕吐。在本研究中，甲氧氯普胺并未加重帕金森病患者的帕金森症状，也未减少左旋多巴引起的不自主运动。相比之下，匹莫齐特加重了帕金森症状并减少了不自主运动。甲氧氯普胺在产生急性运动障碍的同时，显然没有帕金森病效应，这在药理学上是独特的，使该药物与吩噻嗪类和丁酰苯类药物有所区别。
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本文引用的文献
1
[TECHNIC FOR THE STUDY OF THE CENTRAL ACTION OF EMETIC AND ANTIEMETIC POISONS].[催吐药和止吐药中枢作用的研究技术]
C R Seances Soc Biol Fil. 1964;158:964-5.
2
[ANTIEMETIC ACTION OF METOCLOPRAMIDE WITH RESPECT TO APOMORPHINE AND HYDERGINE].[胃复安对阿扑吗啡和海得琴的止吐作用]
C R Seances Soc Biol Fil. 1964;158:723-7.
3
[PROTECTION EXERCISED BY METOCLOPRAMIDE AGAINST THE VOMITIVE EFFECTS OF COPPER SULFATE].[甲氧氯普胺对硫酸铜催吐作用的保护作用]
Pathol Biol. 1964 May;12:577-8.
4
[Clinical and electroencephalographic effects of methoclopramide in psychiatry].甲氧氯普胺在精神病学中的临床及脑电图效应
Therapie. 1965 Jul-Aug;20(4):975-95.
5
Is it possible to predict the clinical effects of neuroleptic drugs (major tranquillizers) from animal data? IV. An improved experimental design for measuring the inhibitory effects of neuroleptic drugs on amphetamine-or apomorphine-induced "Cheroing" and "agitation" in rats.能否从动物实验数据预测抗精神病药物（强效镇静剂）的临床效果？IV. 一种改进的实验设计，用于测量抗精神病药物对大鼠中苯丙胺或阿扑吗啡诱导的“刻板行为”和“激动”的抑制作用。
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6
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7
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8
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10
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