Olivecrona T, Bengtsson-Olivecrona G
Agents Actions Suppl. 1984;16:55-67. doi: 10.1007/978-3-0348-7235-5_7.
The lipoprotein lipase molecule carries several functional sites. Three of these sites, for interaction with lipid interfaces, with activator protein, and with fatty acids, regulate the action of the enzyme's active site. Another, independent, site on the molecule anchors it to cell surface heparan sulfate and thus holds it in place at the endothelium. Together these properties allow for a fine-tuned regulation of the lipoprotein lipase reaction so that lipids are transported from the right particles, into the right tissues at the right rate.
脂蛋白脂肪酶分子带有多个功能位点。其中三个位点分别用于与脂质界面、激活蛋白以及脂肪酸相互作用，从而调节该酶活性位点的作用。分子上另一个独立的位点将其锚定在细胞表面硫酸乙酰肝素上，进而使其在内皮处固定就位。这些特性共同作用，实现了对脂蛋白脂肪酶反应的精细调节，以便脂质以正确的速率从合适的颗粒转运至合适的组织。
