Olivecrona T, Bengtsson-Olivecrona G
Int J Obes. 1985;9 Suppl 1:109-16.
Hydrolysis by lipoprotein lipase in capillaries of the adipose tissue is the step that determines the rate at which fatty acids from lipoprotein triacylglycerols are transported into the tissue for storage. Like many other key enzymes, adipose tissue lipoprotein lipase can be regulated both in amount and in activity. The amount of active lipoprotein lipase at the capillary endothelium is under hormonal control. The enzyme molecule itself carries several functional sites. Three of these sites, for interaction with lipid interfaces, with activator protein, and with fatty acids, regulate the action of the enzyme's active site. Another, independent, site on the molecule anchors it to cell surface heparan sulfate chains and thus holds it in place at the endothelium. Together these properties allow for a fine-tuned regulation of the lipoprotein lipase reaction so that lipids are transferred into the adipose tissue at the right rate, at the right time, and in the right place.
脂肪组织毛细血管中的脂蛋白脂肪酶水解作用，是决定脂蛋白三酰甘油中的脂肪酸转运到该组织进行储存速率的步骤。与许多其他关键酶一样，脂肪组织脂蛋白脂肪酶在数量和活性方面均可受到调节。毛细血管内皮处活性脂蛋白脂肪酶的数量受激素控制。该酶分子本身带有几个功能位点。其中三个位点分别用于与脂质界面、激活蛋白以及脂肪酸相互作用，从而调节酶活性位点的作用。分子上另一个独立的位点将其锚定在细胞表面硫酸乙酰肝素链上，进而使其在内皮处固定就位。这些特性共同实现了对脂蛋白脂肪酶反应的精细调节，以便脂质能在正确的时间、正确的地点以正确的速率转运到脂肪组织中。
