长期饮酒的大鼠急性给予乙醇对乙酰氨基酚代谢及毒性的影响。

Interaction of acute ethanol administration with acetaminophen metabolism and toxicity in rats fed alcohol chronically.

作者信息

Altomare E, Leo M A, Lieber C S

出版信息

Alcohol Clin Exp Res. 1984 Jul-Aug;8(4):405-8. doi: 10.1111/j.1530-0277.1984.tb05688.x.

DOI:10.1111/j.1530-0277.1984.tb05688.x

Abstract

In rats fed alcohol chronically, acetaminophen induced severe hepatotoxicity as judged by serum enzyme activities, liver histology, and mortality, whereas in both rats fed alcohol chronically and in their pair-fed controls, acute ethanol administration decreased acetaminophen hepatotoxicity. Since acetaminophen hepatotoxicity is increased in rats fed alcohol chronically and acute ethanol has been shown to inhibit the biotransformation of acetaminophen to reactive metabolite(s) by mixed function oxidation, we postulate that acute ethanol administration decreases acetaminophen-induced hepatotoxicity in rats fed alcohol chronically by inhibiting the enhanced production of toxic metabolites.

摘要

在长期摄入酒精的大鼠中，根据血清酶活性、肝脏组织学和死亡率判断，对乙酰氨基酚会诱发严重的肝毒性，而在长期摄入酒精的大鼠及其配对喂食的对照大鼠中，急性给予乙醇可降低对乙酰氨基酚的肝毒性。由于长期摄入酒精的大鼠对乙酰氨基酚的肝毒性增强，且已表明急性乙醇可通过混合功能氧化抑制对乙酰氨基酚向反应性代谢物的生物转化，因此我们推测，急性给予乙醇可通过抑制毒性代谢物的过量产生，降低长期摄入酒精的大鼠中对乙酰氨基酚诱发的肝毒性。