Sato C, Izumi N, Nouchi T, Hasumura Y, Takeuchi J
Toxicology. 1985 Feb;34(2):95-101. doi: 10.1016/0300-483x(85)90159-3.
Since caffeine is frequently co-administered with acetaminophen, it is of clinical interest to study the effect of caffeine on the hepatotoxicity of acetaminophen. In male Sprague-Dawley rats fasted for 18 h, concomitant administration of caffeine (0.1 g/kg, i.p.) as judged by increased serum enzyme activities and increased incidence of hepatic necrosis. Careful observations on hepatotoxicity are suggested when acetaminophen is prescribed with caffeine.
由于咖啡因常与对乙酰氨基酚联合使用，因此研究咖啡因对对乙酰氨基酚肝毒性的影响具有临床意义。在禁食18小时的雄性斯普拉格-道利大鼠中，通过血清酶活性升高和肝坏死发生率增加判断，同时给予咖啡因（0.1 g/kg，腹腔注射）。当对乙酰氨基酚与咖啡因合用时，建议仔细观察肝毒性。
