新型聚合物杀菌剂：含侧链双胍基团聚阳离子的合成及抗菌活性
New polymeric biocides: synthesis and antibacterial activities of polycations with pendant biguanide groups.
作者信息
Ikeda T, Yamaguchi H, Tazuke S
出版信息
Antimicrob Agents Chemother. 1984 Aug;26(2):139-44. doi: 10.1128/AAC.26.2.139.
Abstract
Acrylate monomers with pendant biguanide groups were successfully synthesized, and their homopolymers and copolymers were prepared with acrylamide. These cationic disinfectants of polymeric forms exhibited high antibacterial activity against gram-positive bacteria, whereas they were less active against gram-negative bacteria. It was found that the activity of the polymeric disinfectants was much higher than that of the monomeric species, and the difference in activity between the polymers and the monomers was discussed on the basis of their contributions to each elementary process of the lethal action.
摘要
成功合成了带有侧基双胍基团的丙烯酸酯单体，并将其与丙烯酰胺制备成均聚物和共聚物。这些聚合形式的阳离子消毒剂对革兰氏阳性菌表现出高抗菌活性，而对革兰氏阴性菌的活性较低。研究发现，聚合消毒剂的活性远高于单体，基于它们对致死作用各基本过程的贡献，讨论了聚合物与单体之间活性的差异。
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