用鹅去氧胆酸逆转氯贝丁酯诱导的胆汁胆固醇过饱和
Reversal of clofibrate-induced cholesterol oversaturation of bile with chenodeoxycholic acid.
作者信息
Bateson M C, Ross P E, Murison J, Bouchier I A
出版信息
Br Med J. 1978 May 6;1(6121):1171-3. doi: 10.1136/bmj.1.6121.1171.
Abstract
Giving clofibrate 2 g daily to seven patients significantly increased the biliary cholesterol concentration while the proportion of bile acids fell. Five patients on established clofibrate treatment were given 750 mg of chenodeoxycholic acid (CDCA) daily for one month. Biliary lipid analysis after the CDCA treatment showed a significant fall in the proportion of cholesterol and a rise in that of bile acids. The serum lipid concentrations, which had already been reduced by diet and clofibrate, showed a further significant reduction after the introduction of CDCA. This study suggests that CDCA may be usefully combined with clofibrate to reverse the tendency towards cholesterol saturation of bile and enhance the effect of lowering serum lipid concentrations.
摘要
每天给7名患者服用2克氯贝丁酯，可显著提高胆汁胆固醇浓度，同时胆汁酸比例下降。5名接受氯贝丁酯常规治疗的患者，每天服用750毫克鹅去氧胆酸（CDCA），持续1个月。CDCA治疗后的胆汁脂质分析显示，胆固醇比例显著下降，胆汁酸比例上升。已经通过饮食和氯贝丁酯降低的血脂浓度，在引入CDCA后进一步显著降低。这项研究表明，CDCA可能与氯贝丁酯联合使用，有效逆转胆汁胆固醇饱和趋势，并增强降低血脂浓度的效果。
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