Stratas N E
J Clin Psychiatry. 1984 Nov;45(11):466-9.
In a 6-week double-blind parallel treatment study, dothiepin and amitriptyline were compared to placebo in the treatment of 33 depressed outpatients. Dothiepin and amitriptyline were equally effective in alleviating the symptoms of depressive illness, and both were significantly superior to placebo. The overall incidence of side effects and the frequency and severity of blurred vision, dry mouth, and drowsiness were significantly less with dothiepin than with amitriptyline. Dothiepin also produced fewer CNS and cardiovascular effects. There were no clinically important changes in laboratory parameters. Dothiepin thus was found to be an effective antidepressant drug associated with fewer side effects than amitriptyline in the treatment of depressed outpatients.
在一项为期6周的双盲平行治疗研究中，将多塞平与阿米替林用于33例门诊抑郁症患者的治疗，并与安慰剂进行比较。多塞平和阿米替林在缓解抑郁症状方面同样有效，且二者均显著优于安慰剂。与阿米替林相比，多塞平的副作用总发生率以及视力模糊、口干和嗜睡的频率及严重程度均显著更低。多塞平产生的中枢神经系统和心血管系统效应也较少。实验室参数未出现具有临床意义的变化。因此发现，在门诊抑郁症患者的治疗中，多塞平是一种有效的抗抑郁药物，其副作用比阿米替林更少。
