Alleva J J, Lamanna C
J Clin Microbiol. 1984 Sep;20(3):506-8. doi: 10.1128/jcm.20.3.506-508.1984.
Cholera toxin (CT) and the heat-labile enterotoxin from Escherichia coli, when injected intraperitoneally into cycling hamsters but not rats or mice, induced a massive uterine growth similar to that normally induced by the implanting blastocyst during pregnancy. CT and heat-labile enterotoxin are the only known agents that have this action in any species. Uterine weight reached a maximal sixfold increase 48 h after injection of CT. Concurrent injection of estrogen, progesterone, and CT increased the maximal response to eightfold and eliminated differences in the response to CT injected on different days of the 4-day hamster estrous cycle. The dose response for CT, heat-labile enterotoxin, and CT plus estrogen plus progesterone was most linear (r greater than 0.93) when the logarithm of uterine weight was plotted against the dose of toxin. The hamster uterine weight response can serve as a simple, highly precise, and highly specific bioassay for CT and heat-labile enterotoxin.
霍乱毒素（CT）和大肠杆菌不耐热肠毒素经腹腔注射给处于发情周期的仓鼠时，会引起子宫大量生长，类似于怀孕时植入的囊胚正常引起的子宫生长，但对大鼠或小鼠则无此作用。CT和不耐热肠毒素是已知的在任何物种中具有这种作用的仅有的两种物质。注射CT后48小时，子宫重量达到最大六倍的增加。同时注射雌激素、孕酮和CT可使最大反应增加到八倍，并消除了在4天仓鼠发情周期不同天数注射CT时反应的差异。当以子宫重量的对数对毒素剂量作图时，CT、不耐热肠毒素以及CT加雌激素加孕酮的剂量反应最呈线性（r大于0.93）。仓鼠子宫重量反应可作为CT和不耐热肠毒素的一种简单、高度精确且高度特异的生物测定法。
