Welling P G, Tse F L
J Clin Hosp Pharm. 1984 Sep;9(3):163-79. doi: 10.1111/j.1365-2710.1984.tb01075.x.
Apart from the physical and chemical properties of a drug, and also the dosage form in which it is presented, many other factors may affect the absorption of orally administered compounds and give rise to variable systemic availability. Three such factors, gastrointestinal (GI) disease, drug-drug interactions, and drug-food interactions are considered here. Although information regarding these factors, particularly GI disease, is scarce and sometimes conflicting, it is clear that they may give rise to variable drug absorption. The wide spectrum of effects on different drugs precludes the application of general rules and guidelines in drug therapy in most cases. Drugs, dosage forms, and various interactions should be considered individually. Also the types of interactions described in this review must be combined with other factors to be discussed later in this series when considering the influence of variable absorption, distribution, metabolism, and excretion on drug pharmacokinetics and clinical efficacy.
除了药物的物理和化学性质以及其呈现的剂型外，许多其他因素可能会影响口服化合物的吸收，并导致全身可用性的变化。这里考虑三个这样的因素，即胃肠道（GI）疾病、药物相互作用和药物-食物相互作用。尽管关于这些因素的信息，特别是胃肠道疾病的信息稀缺，有时甚至相互矛盾，但很明显它们可能导致药物吸收的变化。对不同药物的广泛影响使得在大多数情况下无法应用药物治疗的一般规则和指南。药物、剂型和各种相互作用应分别考虑。此外，在考虑吸收、分布、代谢和排泄变化对药物药代动力学和临床疗效的影响时，本综述中描述的相互作用类型必须与本系列后面将讨论的其他因素相结合。
