Gubbins P O, Bertch K E
Division of Clinical Practice, College of Pharmacy, University of Kentucky Medical Center, Lexington.
Pharmacotherapy. 1989;9(5):285-95. doi: 10.1002/j.1875-9114.1989.tb04140.x.
It is well recognized that drug absorption from the gastrointestinal tract is influenced by gastric and intestinal motility, surface area available for absorption, and physicochemical properties of the drug. Disease and surgery have been shown to alter these factors. Consequently, drug absorption can be altered as well, and these affect drug therapy. Apparently this effect is variable, but the variability may be due in part to the complexities of performing studies in this area. For example, many patient factors as well as drug characteristics must be considered. In addition, appropriate interpretation of results requires that intravenous data be collected if changes in absorption are based on bioavailability. At this time, the alterations in drug absorption due to gastrointestinal disease and surgery are of unknown or little clinical significance; nevertheless, clinicians should be aware that the possibility of malabsorption exists and anticipate any monitoring of or alterations in therapy that may have to be made.
众所周知，药物从胃肠道的吸收受胃肠蠕动、可用于吸收的表面积以及药物的物理化学性质影响。疾病和手术已被证明会改变这些因素。因此，药物吸收也会改变，进而影响药物治疗。显然这种影响是可变的，但这种变异性可能部分归因于在该领域开展研究的复杂性。例如，必须考虑许多患者因素以及药物特性。此外，如果吸收变化基于生物利用度，则对结果进行恰当解读需要收集静脉注射数据。目前，胃肠道疾病和手术导致的药物吸收改变的临床意义未知或很小；然而，临床医生应意识到存在吸收不良的可能性，并预期可能需要进行的任何治疗监测或调整。
