Groth H E, Shilling J M
J Orthop Res. 1983;1(2):129-35. doi: 10.1002/jor.1100010203.
There has been clinical concern about the gray discoloration in synovial tissue adjacent to carbon-reinforced polyethylene total joint implants. To evaluate the pathologic response of the synovium to this material, synovial specimens from 11 total ankle cases with carbon-reinforced tibial components and two synovial specimens from cases with standard polyethylene tibial components were studied by gross and histologic techniques. Polyethylene debris was found to produce a significant synovial reaction with histiocytes and foreign body giant cells. This was found in both the carbon-reinforced cases and in those cases without carbon-reinforced components. This reaction is also seen in revisions of total hips and total knees in which standard polyethylene components have been implanted. In contrast with this, carbon particles produced only a minimal reaction in the synovial tissue. Carbon appears to be an extremely benign implant material, and synovial discoloration from shed carbon fibrils does not appear to present a significant clinical problem.
临床上一直关注碳增强聚乙烯全关节植入物附近滑膜组织的灰色变色问题。为了评估滑膜对这种材料的病理反应，采用大体和组织学技术对11例使用碳增强胫骨部件的全踝关节病例的滑膜标本以及2例使用标准聚乙烯胫骨部件的病例的滑膜标本进行了研究。发现聚乙烯碎片会引发由组织细胞和异物巨细胞产生的显著滑膜反应。在碳增强病例和无碳增强部件的病例中均发现了这种情况。在植入标准聚乙烯部件的全髋关节和全膝关节翻修病例中也可见到这种反应。与此形成对比的是，碳颗粒在滑膜组织中仅产生极小的反应。碳似乎是一种极其良性的植入材料，脱落的碳原纤维导致的滑膜变色似乎并未构成重大临床问题。
