Thornhill T S, Ozuna R M, Shortkroff S, Keller K, Sledge C B, Spector M
Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Biomaterials. 1990 Jul;11:69-72.
The tissue around loose total joint replacement prostheses displays a synovial-like lining comprised of cells that produce IL-1 and PGE2, mediators of inflammation that stimulate bone resorption. Particles of titanium alloy, as well as cobalt-chromium alloy and polyethylene, were found to aggravate the histiocytic response and production of IL-1 and PGE2. Tissue with similar histological and biochemical features was produced in a canine model of the aseptic loose cemented femoral stem.
松动的全关节置换假体周围的组织呈现出类似滑膜的内衬，由产生白细胞介素-1（IL-1）和前列腺素E2（PGE2）的细胞组成，这两种炎症介质会刺激骨吸收。研究发现，钛合金颗粒以及钴铬合金和聚乙烯颗粒会加剧组织细胞反应以及IL-1和PGE2的产生。在无菌性松动骨水泥固定股骨柄的犬模型中产生了具有相似组织学和生化特征的组织。
