Pehling G B, Gerich J E
Mayo Clin Proc. 1984 Nov;59(11):751-4. doi: 10.1016/s0025-6196(12)65585-2.
The characteristics of plasma free insulin profiles after conventional subcutaneous injection of regular insulin (10 units) and after jet injection of this amount of insulin were compared in eight subjects with insulin-dependent diabetes mellitus. Although administration of insulin with the jet injector resulted in peak plasma free insulin concentrations (45 +/- 4 microU/ml) similar to those achieved after conventional injection (47 +/- 5 microU/ml), it produced more rapid increases in plasma free insulin concentrations (time to peak concentration, 76 +/- 11 minutes versus 152 +/- 16 minutes; P less than 0.01) and less prolonged hyperinsulinemia. Variability in the peak insulin concentrations and the time to peak concentration was comparable for both methods of administration of insulin. Thus, insulin administered by jet injector may improve control of postprandial hyperglycemia and diminish the risk for late hypoglycemia in some patients with insulin-requiring diabetes mellitus treated with conventional injections of insulin.
在8名胰岛素依赖型糖尿病患者中，比较了常规皮下注射10单位普通胰岛素后和喷射注射该剂量胰岛素后血浆游离胰岛素水平的特征。尽管使用喷射注射器给药导致血浆游离胰岛素峰值浓度（45±4微单位/毫升）与常规注射后达到的浓度（47±5微单位/毫升）相似，但它使血浆游离胰岛素浓度升高更快（达到峰值浓度的时间，分别为76±11分钟和152±16分钟；P<0.01），且高胰岛素血症持续时间更短。两种胰岛素给药方法的胰岛素峰值浓度和达到峰值浓度的时间的变异性相当。因此，对于一些接受常规胰岛素注射治疗的胰岛素依赖型糖尿病患者，使用喷射注射器给药胰岛素可能改善餐后高血糖的控制，并降低晚期低血糖的风险。
