Cooper D S
N Engl J Med. 1984 Nov 22;311(21):1353-62. doi: 10.1056/NEJM198411223112106.
Over the past four decades, a great deal has been learned about the pharmacology and mechanisms of action of antithyroid drugs. Their ability to inhibit hormone biosynthesis involves complex interactions with thyroid peroxidase and thyroglobulin, many of which are still poorly understood. Their spectrum of activity is much wider than previously thought, and a number of clinically important extrathyroidal actions have been identified. Despite a greater appreciation for the intricacies of antithyroid-drug pharmacology, controversies still surround the use of these agents in the treatment of thyrotoxicosis. These controversies are apt to continue until the pathophysiology of Graves' disease is fully elucidated.
在过去的四十年里，人们对抗甲状腺药物的药理学及作用机制已有了大量了解。它们抑制激素生物合成的能力涉及与甲状腺过氧化物酶和甲状腺球蛋白的复杂相互作用，其中许多相互作用仍未被充分理解。它们的活性谱比以前认为的要广泛得多，并且已经确定了一些临床上重要的甲状腺外作用。尽管人们对抗甲状腺药物药理学的复杂性有了更深入的认识，但在这些药物用于治疗甲状腺毒症方面仍存在争议。在格雷夫斯病的病理生理学得到充分阐明之前，这些争议可能会持续下去。
