Konkol R J, Mailman R B, Bendeich E G, Garrison A M, Mueller R A, Breese G R
Brain Res. 1978 Apr 14;144(2):277-85. doi: 10.1016/0006-8993(78)90154-3.
Intracisternal NGF or anti-NGF has been found to produce no long-term major alterations in central norepinephrine (NE) or dopamine levels when administered to neonatal rats. While NGF and anti-NGF were found to produce significant changes in brain NE content within one week of treatment, changes in central NE were no longer detectable at 30 days of age. Modification of the growth response of the central adrenergic neurons following 6-OHDA treatment was also not affected by NGF or anti-NGF when evaluated 3 weeks after treatment. However, centrally administered anti-NGF did induce a loss of peripheral NE terminals, which was attributed to leakage of the anti-NGF from the central injection site.
当给新生大鼠注射脑池内神经生长因子（NGF）或抗神经生长因子时，发现其对中枢去甲肾上腺素（NE）或多巴胺水平没有产生长期的重大改变。虽然在治疗一周内发现NGF和抗NGF会使脑内NE含量发生显著变化，但在30日龄时已检测不到中枢NE的变化。在6-羟基多巴胺（6-OHDA）治疗后评估，中枢肾上腺素能神经元的生长反应改变在治疗3周后也不受NGF或抗NGF的影响。然而，脑内注射抗NGF确实会导致外周NE末梢的丧失，这归因于抗NGF从脑内注射部位渗漏。
