Umeda T, Inaba T
Can J Physiol Pharmacol. 1978 Apr;56(2):241-4. doi: 10.1139/y78-035.
The effects of diethyl ether and urethane on the elimination of diphenylhydantoin (DPH) in the rat were compared. The apparent half-life of DPH following a dose of 10 mg/kg, iv, under continuous ether anesthesia was 284 +/- 47 min, while the half-life under urethane anesthesia was 25.5 +/- 6.3 min. The latter was in agreement with the literature value for DPH half-life without anesthesia. The effects of both anesthetic agents on bile flow and indocyanine green clearance were not different. Following intravenous administration of DPH (1 mg/kg), DPH metabolites excreted in bile at 2 h were 75.3 +/- 4.8% of the dose with urethane anesthesia and 25.0 +/- 5.0% of the dose with continuous ether anesthesia. The data suggest that ether may inhibit the DPH metabolism in vivo, most likely at the hydroxylation step, while urethane does not.
比较了乙醚和氨基甲酸乙酯对大鼠体内苯妥英（DPH）消除的影响。静脉注射10mg/kg剂量的DPH后，在持续乙醚麻醉下，DPH的表观半衰期为284±47分钟，而在氨基甲酸乙酯麻醉下的半衰期为25.5±6.3分钟。后者与无麻醉情况下DPH半衰期的文献值一致。两种麻醉剂对胆汁流量和吲哚菁绿清除率的影响无差异。静脉注射DPH（1mg/kg）后，在2小时时，氨基甲酸乙酯麻醉下胆汁中排泄的DPH代谢产物占剂量的75.3±4.8%，持续乙醚麻醉下占剂量的25.0±5.0%。数据表明，乙醚可能在体内抑制DPH代谢，最有可能是在羟基化步骤，而氨基甲酸乙酯则不会。
