Hanew T, Schenker S, Meredith C G, Henderson G I
Proc Soc Exp Biol Med. 1984 Jan;175(1):64-9. doi: 10.3181/00379727-175-41767.
Our studies in rats clearly demonstrate a significant depression of aminopyrine metabolism in vivo by ether anesthesia. The depression of aminopyrine elimination was shown both by measurements of plasma aminopyrine clearance and by depression of the [14C]aminopyrine breath test. No apparent effect of ether was seen on aminopyrine volume of distribution. The effect of ether was prolonged, as judged by its persistence in the aminopyrine breath test for 3 hr after stopping ether anesthesia. In addition, when ether was administered in combination with a single dose of ethanol, aminopyrine clearance was inhibited significantly more than with ethanol alone. These data not only have a bearing on proper methodologic design of drug clearance studies but also may relate to the effects of some anesthetics on hepatic function.
我们在大鼠身上的研究清楚地表明，乙醚麻醉会使体内氨基比林代谢显著降低。通过测量血浆氨基比林清除率以及[14C]氨基比林呼气试验的降低，均显示出氨基比林消除的减少。未观察到乙醚对氨基比林分布容积有明显影响。根据在停止乙醚麻醉后3小时的[14C]氨基比林呼气试验中其持续存在判断，乙醚的作用持续时间较长。此外，当乙醚与单剂量乙醇联合使用时，氨基比林清除率受到的抑制明显大于单独使用乙醇时。这些数据不仅与药物清除率研究的正确方法学设计有关，还可能与某些麻醉剂对肝功能的影响有关。
