Lang A E, Blair R D
Can Med Assoc J. 1984 Nov 1;131(9):1031-7.
This update reviews several important topics in the field of Parkinson's disease, including etiologic studies, the types and mechanisms of drug complications and their treatment, when and how to begin treatment, the association of dementia with Parkinson's disease, and the development of the newer research tools. The recent discovery of a highly selective neurotoxin (MPTP) that causes parkinsonism in humans and other primates and the use of positron emission tomography in living patients should improve our understanding of the cause of cell death in Parkinson's disease and assist in the development of more definitive treatment for this common, disabling neurologic condition.
本次更新回顾了帕金森病领域的几个重要主题,包括病因学研究、药物并发症的类型及机制及其治疗、何时以及如何开始治疗、痴呆与帕金森病的关联以及新型研究工具的发展。最近发现一种能在人类和其他灵长类动物中导致帕金森综合征的高选择性神经毒素(MPTP),以及在活体患者中使用正电子发射断层扫描,应该会增进我们对帕金森病细胞死亡原因的理解,并有助于为这种常见的、使人致残的神经系统疾病开发更确切的治疗方法。