Barbeau A, Pourcher E
Can J Neurol Sci. 1982 Feb;9(1):53-60. doi: 10.1017/s031716710004364x.
We investigated the clinical and metabolic characteristics of Parkinsonian patients whose illness started before the age of 40. A pilot study of 32 of our own such cases revealed the existence of 3 subgroups: 1. Post-Encephalitic, 2. Onset and course with predominant tremor, 3. Onset and course with akinesia and rigidity. In this early onset group of patients, there was a 46% incidence of familial cases (as opposed to 10-15% in the general Parkinson populations). The cases with tremor onset had a high prevalence of essential tremor in their families, while those with an akineto-rigid onset had a high familial incidence of other cases of Parkinson's Disease. Familial grey hair, hypertension, diabetes and thyroidopathies appeared to be in higher than expected frequency.
我们研究了40岁之前发病的帕金森病患者的临床和代谢特征。对我们自己的32例此类病例进行的一项初步研究发现存在3个亚组：1. 脑炎后型；2. 以震颤为主的起病和病程型；3. 以运动不能和强直为主的起病和病程型。在这个早发型患者组中，家族性病例的发生率为46%（而帕金森病总体人群中的发生率为10%-15%）。震颤起病的病例在其家族中特发性震颤的患病率较高，而运动不能-强直起病的病例在家族中帕金森病其他病例的发生率较高。家族性白发、高血压、糖尿病和甲状腺疾病的出现频率似乎高于预期。
