Dysfibrinogenemia. A current perspective.

At least 24 single amino acid substitution dysfibrinogens are currently known. Emerging evidence supports conclusions reached from studies on normal fibrinogen, which relate to the importance of release of A peptides to formation of a physiologically adequate fibrin clot; the existence of "D-D" or (b-b) polymerization sites; and the importance of the gamma chain carboxy terminal segment in fibrin assembly.