Erenpreĭs Ia G
Eksp Onkol. 1984;6(3):10-4.
The data on the induction of normalization of tumour cells in terms of their ability to be morphologically and functionally incorporated into normal tissues and organs are reviewed. Such a process, though usually connected with differentiation of tumour cells, is not identical to that. Two groups of data are considered--normalization of tumour cells under morphogenic factors of embryonal development and that under reparative regeneration factors. The ability of tumour cells to undergo normalization in the embryonic morphogenic field is quite evident; the general regularities of the process are stated, and main efforts are aimed at widening the spectrum of the tumours involved into normal embryogenesis. In experiments with reparative regeneration only preliminary results have been obtained.
本文综述了有关肿瘤细胞形态和功能上整合到正常组织和器官从而诱导肿瘤细胞正常化的数据。虽然这一过程通常与肿瘤细胞的分化相关，但二者并不相同。文中考虑了两组数据——胚胎发育形态发生因子作用下肿瘤细胞的正常化以及修复再生因子作用下肿瘤细胞的正常化。肿瘤细胞在胚胎形态发生场中发生正常化的能力相当明显；阐述了该过程的一般规律，主要致力于扩大参与正常胚胎发生的肿瘤谱。在修复再生实验中仅获得了初步结果。
