Eisenhauer T, Hartmann H, Rumpf K W, Helmchen U, Scheler F, Creutzfeldt W
Digestion. 1984;30(3):185-90. doi: 10.1159/000199104.
Veno-occlusive disease (VOD) developed in a 45-year-old white male 2 years after cadaveric kidney transplantation while receiving combined immunosuppressive therapy with prednisone and azathioprine. Early clinical signs at presentation included ascites and tender hepatomegaly. The diagnosis of VOD was established at laparoscopy and by histological examination of liver biopsies. Azathioprine was discontinued. Gross ascites refractory to medical treatment and decreasing liver function required surgical treatment by portacaval shunt. Transient postoperative complications were hepatic encephalopathy and considerable hyperbilirubinaemia. 8 months later the patient is well, with stable renal function and no clinical signs of hepatic disease.
一名45岁白人男性在尸体肾移植2年后，接受泼尼松和硫唑嘌呤联合免疫抑制治疗时发生了肝静脉闭塞病（VOD）。出现的早期临床症状包括腹水和肝肿大压痛。通过腹腔镜检查和肝活检组织学检查确诊为VOD。停用硫唑嘌呤。因大量腹水药物治疗无效且肝功能下降，需行门腔分流术进行手术治疗。术后短暂出现肝性脑病和明显高胆红素血症。8个月后患者情况良好，肾功能稳定，无肝病临床症状。
