Bullen J J
Rev Infect Dis. 1981 Nov-Dec;3(6):1127-38. doi: 10.1093/clinids/3.6.1127.
The iron-binding proteins transferrin and lactoferrin restrict the amount of ionic iron available in body fluids to 10(-18) M. This amount is insufficient for normal bacterial growth, and pathogens acquire iron either by producing iron-chelating agents or by utilizing heme compounds. Iron-binding proteins, in combination with antibodies, often have powerful bacteriostatic effects in vitro and are essential for protection against many infections. Lactoferrin appears to be essential for the bactericidal function of polymorphonuclear leukocytes against Pseudomonas aeruginosa. Fever lowers the concentration of iron in serum and favors resistance to infection. Liberation of heme compounds can enhance clinical infections.
铁结合蛋白转铁蛋白和乳铁蛋白将体液中可利用的离子铁量限制在10^(-18) M。这个量不足以支持正常细菌生长，病原体通过产生铁螯合剂或利用血红素化合物来获取铁。铁结合蛋白与抗体结合，在体外通常具有强大的抑菌作用，对于抵御多种感染至关重要。乳铁蛋白似乎对于多形核白细胞对铜绿假单胞菌的杀菌功能必不可少。发热会降低血清中铁的浓度，有利于抗感染。血红素化合物的释放会加重临床感染。
