Sugarman B, Epps L R
J Med Microbiol. 1984 Dec;18(3):393-8. doi: 10.1099/00222615-18-3-393.
Enterotoxigenic Escherichia coli is a major cause of diarrhoea in man. When zinc in concentrations of 10(-6) M or 10(-5) M was added to the growth medium, there was a significant increase in heat-labile enterotoxin production by each of six toxigenic strains. Zinc in these concentrations did not alter bacterial growth or the activity of preformed toxin. Other heavy metals did not enhance toxin production and o-phenanthroline, a relatively specific zinc-chelating compound, blocked the enhancing effect. The significance of these findings is discussed in relation to the use of supplemental dietary zinc.
产肠毒素大肠杆菌是人类腹泻的主要病因。当向生长培养基中添加浓度为10⁻⁶ M或10⁻⁵ M的锌时，6株产毒菌株中的每一株产生的不耐热肠毒素均显著增加。这些浓度的锌不会改变细菌生长或已形成毒素的活性。其他重金属不会增强毒素产生，而相对特异性的锌螯合化合物邻菲罗啉会阻断这种增强作用。结合膳食锌补充剂的使用对这些发现的意义进行了讨论。
