Narang P K, Hunter J R
Rev Infect Dis. 1984 Sep-Oct;6(5):732-5. doi: 10.1093/clinids/6.5.732.
Ceftazidime is a third-generation cephalosporin that is eliminated primarily via the kidneys. Several studies have indicated that dosage adjustment is necessary in patients with renal disease. The correlation between the glomerular filtration rate and half-life (t 1/2) developed by Norrby and co-workers was used to evaluate, in three patients, the hypothesis that renal function is the principal determinant in excretion of the ceftazidime. Results obtained indicate that although the correlation appeared valid for a patient with chronic renal failure it did not predict patterns of ceftazidime elimination in two granulocytopenic patients with lymphoma. Therefore, caution should be exercised when employing Norrby's correlation for adjusting ceftazidime dosage for patients with certain disease states.
头孢他啶是一种第三代头孢菌素，主要通过肾脏排泄。多项研究表明，肾病患者需要调整剂量。诺尔比及其同事得出的肾小球滤过率与半衰期（t1/2）之间的相关性，被用于评估3例患者的肾功能是否是头孢他啶排泄的主要决定因素这一假设。所得结果表明，尽管这种相关性对一名慢性肾衰竭患者似乎有效，但它并未预测出两名淋巴瘤粒细胞减少症患者的头孢他啶消除模式。因此，在使用诺尔比的相关性为某些疾病状态的患者调整头孢他啶剂量时应谨慎。
