Heim-Duthoy K L, Bubrick M P, Cocchetto D M, Matzke G R
Drug Evaluation Unit, Hennepin County Medical Center, Minneapolis, Minnesota 55415.
Antimicrob Agents Chemother. 1988 Dec;32(12):1845-7. doi: 10.1128/AAC.32.12.1845.
The disposition of ceftazidime was assessed in 11 surgical patients with suspected intra-abdominal infection. All patients had normal hepatic function, and creatinine clearances ranged from 43 to 186 ml/min. Patients received 2 g of ceftazidime intravenously every 8 h. Trough and peak concentrations in serum were measured on day 2, and trough and postdose concentrations in serum were determined on 10 samples collected during a dosage interval between days 3 and 6 of therapy. Ceftazidime peak and trough concentrations in serum at steady state determined by high-performance liquid chromatography were 257.4 +/- 122.0 (mean +/- standard deviation) and 13.1 +/- 20.6 mg/liter. The serum-concentration-versus-time profile was multiexponential. The elimination half-life, steady-state volume of distribution, and total body clearance were 2.52 +/- 1.39 h, 0.31 +/- 0.12 liter/kg, and 0.11 +/- 0.05 liter/h per kg, respectively. Total predicted body clearance significantly correlated with the measured values (r = 0.868; P = 0.001). The disposition of ceftazidime is dependent on creatinine clearance and is not significantly altered by surgery or acute infectious processes.
对11例疑似腹腔内感染的外科手术患者的头孢他啶处置情况进行了评估。所有患者肝功能均正常，肌酐清除率范围为43至186 ml/分钟。患者每8小时静脉注射2g头孢他啶。在第2天测量血清中的谷浓度和峰浓度，并在治疗第3天至第6天的给药间隔期间采集的10份样本中测定血清中的谷浓度和给药后浓度。通过高效液相色谱法测定的稳态时血清中头孢他啶的峰浓度和谷浓度分别为257.4±122.0（平均值±标准差）和13.1±20.6mg/升。血清浓度-时间曲线为多指数曲线。消除半衰期、稳态分布容积和全身清除率分别为2.52±1.39小时、0.31±0.12升/千克和0.11±0.05升/小时/千克。预测的总全身清除率与测量值显著相关（r = 0.868；P = 0.001）。头孢他啶的处置情况取决于肌酐清除率，不受手术或急性感染过程的显著影响。
