Sherban S D, Struk V I
Eksp Onkol. 1984;6(5):3-9.
Modern investigations of structural and functional organization of oncoviruses are analyzed. The data available in the literature on oncovirus interaction with host cell membrane (adsorption, penetration by endocytosis and fusion, uncoating) as well as the cell and viral receptors are elucidated. The results of the studies on retroviral organization of genome, its integration with cellular genome, transcription and translation are given. The functions of long terminal repeats are described. The characteristic of the end step of life cycle of retroviruses (assembly, budding and maturation) is presented.
分析了对肿瘤病毒结构和功能组织的现代研究。阐明了文献中关于肿瘤病毒与宿主细胞膜相互作用(吸附、通过内吞作用和融合进行穿透、脱壳)以及细胞和病毒受体的现有数据。给出了关于逆转录病毒基因组组织、其与细胞基因组整合、转录和翻译的研究结果。描述了长末端重复序列的功能。介绍了逆转录病毒生命周期终末步骤(组装、出芽和成熟)的特征。