Gauger J
Dermatologische Klinik und Poliklinik, Technischen Universität München.
Hautarzt. 1988 May;39(5):270-6.
Genetic information on the AIDS virus, which belongs to the family of retroviruses, is encoded in a single-strand RNA. After infection of the target cell, its genomic RNA is transcribed into DNA by the reverse transcriptase. Subsequently, the DNA can be integrated into the host genome. This viral genome encodes the envelope proteins, the core proteins and the viral enzymes. There are additional genes coding for products which have regulatory functions and determine the interaction between virus and host cell. The replication cycle of the AIDS virus begins with infection of the target cell. After transcription by the reverse transcriptase, the genetic viral information may remain latent or may, under certain circumstances, lead to the expression of viral components which can be assembled at the cell membrane. New viruses are then formed by budding. Theoretically, each step in the viral replication cycle could serve as a target of therapeutic intervention. Up to now, only a few compounds have been investigated in clinical studies.
艾滋病病毒属于逆转录病毒科，其遗传信息编码在单链RNA中。感染靶细胞后，其基因组RNA通过逆转录酶转录为DNA。随后，DNA可整合到宿主基因组中。这种病毒基因组编码包膜蛋白、核心蛋白和病毒酶。还有一些基因编码具有调节功能并决定病毒与宿主细胞相互作用的产物。艾滋病病毒的复制周期始于靶细胞的感染。在逆转录酶转录后，病毒遗传信息可能保持潜伏状态，或在某些情况下导致病毒成分的表达，这些成分可在细胞膜上组装。然后通过出芽形成新的病毒。理论上，病毒复制周期中的每一步都可作为治疗干预的靶点。到目前为止，只有少数化合物在临床研究中得到了研究。
