用舒必利试验评估垂体性侏儒症患者的催乳素释放情况。

Assessment of prolactin release in pituitary dwarfism with the sulpiride test.

作者信息

Batrinos M L, Pavlou S N, Pitoulis S A, Sfikaki A P, Anousakis C, Alexandrides T K, Piaditis G P

出版信息

Clin Endocrinol (Oxf). 1978 Mar;8(3):197-205. doi: 10.1111/j.1365-2265.1978.tb01495.x.

DOI:10.1111/j.1365-2265.1978.tb01495.x

Abstract

We report here the results obtained with a new test of prolactin (PRL) release in six normal pre-pubertal boys, eleven children with short stature of non-pituitary origin and in thirteen pituitary dwarfs. The test consists of the administration of 100 mg of sulpiride i.m. and the measurement of PRL in serum samples up to 120 min after injection. Baseline PRL concentrations were not clearly different in the three groups. After sulpiride a marked increase (3--10 times over control values) in PRL was noted in all normal and short children without pituitary disease. A complete failure of response was observed in ten of the thirteen pituitary dwarfs. It is concluded that sulpiride has considerable potential in the differential diagnosis of children with stunted growth.

摘要

我们在此报告一项针对6名正常青春期前男孩、11名非垂体源性身材矮小儿童以及13名垂体性侏儒症患儿进行的催乳素（PRL）释放新测试的结果。该测试包括肌肉注射100毫克舒必利，并在注射后长达120分钟内测量血清样本中的PRL。三组的基础PRL浓度无明显差异。注射舒必利后，所有正常和无垂体疾病的身材矮小儿童的PRL均显著升高（比对照值高3至10倍）。13名垂体性侏儒症患儿中有10名完全无反应。结论是，舒必利在生长发育迟缓儿童的鉴别诊断中具有相当大的潜力。