Richards A M, Nicholls M G, Espiner E A, Ikram H, Maslowski A H, Hamilton E J, Wells J E
Clin Exp Pharmacol Physiol. 1984 Jul-Aug;11(4):375-9. doi: 10.1111/j.1440-1681.1984.tb00282.x.
Continuous 24 h arterial blood pressure and vasoactive hormones were measured in twelve patients with essential hypertension after 4 weeks on a control sodium intake (180 mmol/day) and after similar periods of sodium restriction (80 mmol/day) and potassium supplementation (200 mmol/day). Sodium restriction was associated with variable blood pressure changes in individual patients and a small reduction in 24 h mean pressure of 4/3 mmHg. The greatest fall in blood pressure with sodium restriction was seen in those patients with the least rise in renin. Potassium supplementation was associated with variable individual blood pressure changes and a trivial reduction in mean 24 h pressures (0.1/0.8 mmHg). Mean 24 h plasma aldosterone concentration was significantly higher during sodium restricted and potassium-supplemented diets, compared to control levels, but other vasoactive hormones were unchanged.
对12例原发性高血压患者进行了研究，在钠摄入量控制在180 mmol/天（持续4周）后，以及在类似时长的钠限制（80 mmol/天）和钾补充（200 mmol/天）后，测量了他们24小时的连续动脉血压和血管活性激素水平。钠限制与个体患者血压的不同变化相关，24小时平均血压小幅下降4/3 mmHg。在肾素升高最少的患者中，钠限制导致的血压下降最为明显。钾补充与个体血压的不同变化相关，24小时平均血压轻微下降（0.1/0.8 mmHg）。与对照水平相比，在钠限制和钾补充饮食期间，24小时血浆醛固酮平均浓度显著升高，但其他血管活性激素未发生变化。
